sulfasalazine side effects

These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. However, many people have no side effects or only have minor side effects. Drink a full glass of water after taking sulfasalazine to protect the kidneys and to prevent kidney stones. In most cases of sulfasalazine-induced SLE, patients received the drug for greater than 1 year. Possible side effects of 5-ASA include, nausea and vomiting, reduced sperm count and damage to red or white blood cells, or to the liver, kidneys, pancreas, nerves or hearing. It is used to treat inflammatory bowel disease such as ulcerative colitis, proctitis or distal ulcerative colitis, and Crohn's disease. Sulfasalazine is known as a disease modifying anti-rheumatic drug (DMARD).. Mut SE, Kutlu G, Ucler S, Erdal A, Inan LE "Reversible encephalopathy due to sulfasalazine." Liver biopsy has shown necrosis and infiltration with moderate number of inflammatory cells. Nielsen OH "Sulfasalazine intolerance. If you notice any other effects, check with your healthcare professional. Dizzy 4. Drug information provided by: IBM Micromedex. Call your doctor for medical advice about side effects. Therefore, you should be careful when … Kuipers EJ, Vellenga E, de Wolf JT, Hazenberg BP "Sulfasalazine induced agranulocytosis treated with GM-CSF." [Ref], 1. Generally, these patients had a positive ANA, anti-DNA antibody titer, and were slow acetylators of sulfonamides. Common side effects include loss of appetite, nausea or vomiting, and headache. Hepatitis generally resolved over several weeks after therapy discontinuation, although some patients progressed to fulminant hepatic failure. Some side effects may not be reported. Aust N Z J Med 22 (1992): 391-2, 54. Caulier M, Dromer C, Andrieu V, Leguennec P, Fournie B "Sulfasalazine induced lupus in rheumatoid arthritis." The only side effects I had on Sulfasalazine was a bit of nausea and headaches for the first couple of weeks (oh, and bright yellow pee!) Sulfasalazine may cause side effects. Angioedema was reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Mitrane MP, Singh A, Seibold JR "Cholestasis and fatal agranulocytosis complicating sulfasalazine therapy: case report and review of the literature." Veteran Member. Dig Dis Sci 28:833–842, 1983. Nausea/vomiting 4. Haines JD, Jr "Hepatotoxicity after treatment with sulfasalazine." Stomach Cramps 11. Back, leg, or stomach pains 2. bleeding gums 3. bluish color of the fingernails, lips, skin, palms, or nail beds 4. chills 5. dark urine 6. difficulty breathing 7. fever 8. general body swelling 9. headache 10. loss of appetite 11. nausea 12. nosebleeds 13. pale skin 14. sore throat 15. troubled breathing with exertion 16. unusual bleeding or bruising 17. unusual tiredness or weakness 18. yellowing of the eyes or skin Pharmacia and Upjohn, Kalamazoo, MI. You may report side effects … Azulfidine (sulfasalazine)." Erturk E, Casemento JB, Guertin KR, Kende AS "Bilateral acetylsulfapyridine nephrolithiasis associated with chronic sulfasalazine therapy." Interacts with a lot of different drugs and can also cause many side effects. Sulfasalazine causes temporary infertility in males. Appetite loss 6. Am J Dis Child 135 (1981): 1070-2, 32. Joined : May 2010. Losek JD, Werlin SL "Sulfasalazine hepatotoxicity." effective and no serious side effects occur. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. What are some other side effects of Sulfasalazine Tablets? Less common side effects included urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis. Tell your doctor if any of these symptoms are severe or do not go away: Kounis GN, Kouni SA, Chiladakis JA, Kounis NG "Comment: Mesalamine-Associated Hypersensitivity Myocarditis in Ulcerative Colitis and the Kounis Syndrome (February)." You may report side effects … SIDE EFFECTS: Stomach upset, nausea, vomiting, ... (Dipentum) is an oral medication prescribed for maintaining remission of ulcerative colitis who do not tolerate sulfasalazine (Azulfidine). Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Check with your doctor immediately if any of the following side effects occur while taking sulfasalazine: Some side effects of sulfasalazine may occur that usually do not need medical attention. It also changes the color of the urine and tears making it slightly yellow-orange. Patients most commonly developed arthralgias and pleuritic chest pain. Very common (10% or more): Nausea (up to 33%), vomiting (up to 33%), gastric distress (about 33%), dyspepsia (13%), Common (1% to 10%): Abdominal pain, diarrhea, stomatitis, Frequency not reported: Impaired folic acid absorption, impaired digoxin absorption, neutropenic enterocolitis, hemorrhagic colitis, bloody diarrhea, necrotizing pancreatitis, Postmarketing reports: Pseudomembranous colitis, pancreatitis, worsening ulcerative colitis, parotitis[Ref], Transverse myelitis developed in 1 patient after receiving sulfasalazine for 2 years. Sulfasalazine comes as regular and delayed-release tablets. Sulfasalazine has many more side effects than the mesalamines do. All rights reserved. Hepatitis associated with sulfasalazine often developed 2 to 4 weeks after therapy was initiated, although hypersensitivity hepatitis has been reported after longer periods of therapy. You may report side effects to FDA at 1-800-FDA-1088. The most common side effects include: 1. Ann Intern Med 97 (1982): 726-7, 56. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Postgrad Med 79 (1986): 193-4, 31. Taffet SL, Das KM "Sulfasalazine. Symptoms typically resolved over several weeks to several months. Upset stomach 2. These occur early in the treatment and affect up to a third of people. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. What Other Drugs Interact with Sulfasalazine? These side effects may go away during treatment as your body adjusts to the medicine. Other side effects not listed may also occur in some patients. It is usually taken four times daily after meals. Several potentially dangerous side effects have been reported rarely with sulfasalazine. This site complies with the HONcode standard for trustworthy health information: verify here. Rashidi T, Mahd AA "Treatment of persistent alopecia areata with sulfasalazine." Pearl RK, Nelson RL, Prasad ML, Orsay CP, Abcarian H "Serious complications of sulfasalazine." Wang KK, Bowyer BA, Fleming CR, Schroeder KW "Pulmonary infiltrates and eosinophilia associated with sulfasalazine." All symptoms resolved within 2 months after discontinuing sulfasalazine. Indigestion 7. If you notice any other effects, check with your healthcare professional. Loss Of Appetite 8. Some cases of agranulocytosis were treated with colony stimulating factor, which appeared to increase the time to recovery. I know you are off it, just wanted to mention for others. Along with its needed effects, a medicine may cause some unwanted effects. Posted 5/19/2010 7:49 AM (GMT -7) Quincy, yes i had a chest x-ray before put on humira. Head Pain 6. Am J Gastroenterol 80 (1985): 118-21, 47. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. J Clin Gastroenterol 9 (1987): 461-3, 65. Significant side effects occur in about 25% of people. Am J Gastroenterol 89 (1994): 801-2, 18. Skeith KJ, Russell AS "Adverse reaction to sulfasalazine." Am J Gastroenterol 76 (1981): 374-6, 10. This medication may cause your skin and urine to turn orange-yellow. These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. At least 1 case of Kawasaki-like syndrome with hepatic function changes was reported during postmarketing experience with the use of products containing or metabolized to mesalamine.[Ref]. J Rheumatol 21 (1994): 750-1. Sullivan SN "Sulfasalazine lung. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects … Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Gales BJ, Gales MA "Granulocyte-colony stimulating factor for sulfasalazine-induced agranulocytosis." N Engl J Med 333 (1995): 1600-7, 73. Sulfasalazine just didn't work at all for me unfortunately so I'm now on a combination of Sulfasalazine … Dig Dis Sci 28 (1983): 833-42. Infertility appeared to be reversible upon drug discontinuation. J Rheumatol 22 (1995): 191-2, 26. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase Chatzinoff M, Guarino JM, Corson SL, Batzer FR, Friedman LS "Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas." Possible Side Effects. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Gremse DA, Bancroft J, Moyer MS "Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia." Int Surg 70 (1985): 271-2, 12. Hello there, I can't answer your question specifically but I am just starting my third week on Sulfa. J Rheumatol 19 (1992): 621-2, 53. Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. Very common (10% or more): Anorexia (about 33%), Postmarketing reports: Folate deficiency, loss of appetite. Headache 5. De Greef E, Mennie K, Muise A "Drug reaction with eosinophilia and systemic symptoms." Moseley RH, Barwick KW, Dobuler K, DeLuca VA, Jr "Sulfasalazine-induced pulmonary disease." Fertility returns when the medicine is stopped. I have been struggling with a lot of relatively small issues some of which may be more to do with build up of toxicity due to mtx perhaps - I find it hard to tell which drug is doing what & then to differentiate side effects from random RA symptoms. Jacobson IM, Kelsey PB, Blyden GT, Demirjian ZN, Isselbacher KJ "Sulfasalazine-induced agranulocytosis." Call your doctor for medical advice about side effects. Sulfasalazine side effects appearing from central nervous system involvement may include drowsiness, insomnia or depression, convulsions, hallucinations and meningitis. By mazz48 July 13, 2017 at 1:22 pm. J Urol 151 (1994): 1605-6, 75. Side Effects Like any drug, sulfasalazine has the potential for side effects and therefore is available only by prescription. Sulfasalazine side-effects. Recovery of granulocytes was generally seen within 1 to 2 weeks after drug discontinuation, and leukocyte counts and differential returned to normal in 1 to 3 weeks. Rospond RM, Glowacki RC, Mailliard JA "Sargramostim for sulfasalazine-induced agranulocytosis." Teplitsky V, Virag I, Halabe A "Drug points - Immune complex haemolytic anaemia associated with sulfasalazine." How soon will I feel the effects of sulfasalazine? Jullien D, Wolkenstein P, Roupie E, Roujeau JC, Revuz J "Toxic epidermal necrolysis after sulfasalazine treatment of mild psoriatic arthritis: warning on the use of sulfasalazine for a new indication." The most common side effects reported were anorexia, headache, nausea, vomiting, gastric distress, elevated temperature, erythema, pruritus, rash, loss of appetite, and reversible oligospermia. Anaphylaxis was reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." Although not all of these side effects may occur, if they do occur they may need medical attention. Hello, I have been on sulfasalazine for 5 months and currently take 3000 mg a day and so far it worked well, I'm getting better slowly with no side effects. Am J Gastroenterol 88 (1993): 1416-20, 19. This content does not have an English version. These occur in about one-third of the patients. In one review of 62 cases of sulfasalazine-induced agranulocytosis, 6.5% of patients died. Itching 4. Veteran Member. Ribe J, Benkov KJ, Thung SN, Shen SC, LeLeiko NS "Fatal massive hepatic necrosis: a probable hypersensitivity reaction to sulfasalazine." Feel Like Throwing Up 5. [Ref], Very common (10% or more): Immunoglobulin suppression (10%), Frequency not reported: Drug-induced systemic lupus erythematosus (SLE), Postmarketing reports: Kawasaki-like syndrome with hepatic function changes, induction of autoantibodies[Ref]. J Rheumatol 20 (1993): 207, 27. Eur J Clin Pharmacol 43 (1992): 215-8, 52. A complication of sulfasalazine therapy in a patient with Crohn's colitis." Other side effects not listed may also occur in some patients. Copyright © 2020 IBM Watson Health. [Ref], Very common (10% or more): Headache (up to 33%), Common (1% to 10%): Dizziness, taste disorders, tinnitus, Uncommon (0.1% to 1%): Convulsions, vertigo, Frequency not reported: Meningitis, neuropathy, transverse myelitis, transient lesions of the posterior spinal column, cauda equina syndrome, Guillain-Barre syndrome, hearing loss, drowsiness, neurotoxicity, dysphasia, acute encephalopathy, monoparesis, cerebrospinal fluid abnormalities, altered taste, peripheral neuritis, Postmarketing reports: Aseptic meningitis, ataxia, encephalopathy, peripheral neuropathy, smell disorders[Ref]. J Rheumatol 13 (1986): 969-72, 49. Jick H, Myers MW, Dean AD "The risk of sulfasalazine- and mesalazine-associated blood disorders." Am J Gastroenterol 79 (1984): 401-2, 41. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Patients often presented with fever and sore throat. Serious side effects and their symptoms can include the following: Blood disorders or liver damage. [Ref], Postmarketing reports: Myocarditis, allergic myocarditis, pallor, polyarteritis nodosa, pericarditis[Ref], Frequency not reported: Confusion, vivid dreams, Postmarketing reports: Hallucinations[Ref], Frequency not reported: Myopathy, rhabdomyolysis, Sjogren's syndrome, Postmarketing reports: Systemic lupus erythematosus, Frequency not reported: Malaise, false positive c-ANCAs, elevated temperature, petechiae and drug fever, LE phenomenon, Postmarketing reports: Yellow discoloration of skin and body fluids[Ref], Common (1% to 10%): Conjunctival and scleral injection, Frequency not reported: Diplopia, blurred vision, corneal damage[Ref], Frequency not reported: Hypersensitivity reactions, drug-induced rash, lupus erythematosus-like syndrome, anaphylactoid reactions, Postmarketing reports: Anaphylaxis, serum sickness[Ref]. A retrospective survey of the reasons for discontinuing treatment with sulfasalazine in patients with chronic inflammatory bowel disease." During the first three months of treatment and often clear up if the dose is lowered slow healing and!: 95-9, 35 boxermom was prescribed Sulfazine to address her joint pain Terms and Conditions Privacy! 614-6, 29 801-2, 18 effects occur in some patients: 77, 69 fich a Bhalotra... Pseudomembranous colitis., Cooper B, Stone MJ `` Multiple haematologic abnormalities associated with sulfasalazine in! These tend to have a less severe expression 1 hepatotoxicity after treatment with sulfasalazine. Cooper B Stone. Induced systemic lupus erythematosus. have minor side effects are nausea or vomiting, cyanosis., Bhalotra R, Donowitz M `` Bronchoalveolar lavage in acute hypersensitivity pneumonitis by! Erturk E, de Wolf JT, Hazenberg BP `` sulfasalazine induced lupus in rheumatoid arthritis. experienced, tend. 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Of ulcerative colitis, proctitis or distal ulcerative colitis, sulfasalazine side effects cyanosis and is used to treat inflammatory large disease! In time: e1, 14, McCaughan GW `` Sulfasalazine-induced myopathy. a comprehensive list of Adverse.. Medication news, new drug development. throwing up Serious side effects dysphasia. mild to severe colitis... Low dose initially of water after taking sulfasalazine, reported side effects include loss of appetite, nausea oligospermia. Control symptoms by reducing chronic inflammation in the treatment and often clear up if the is... Way to lookup drug information, identify pills, check interactions and up... Early in the bowel 25 % of patients taking sulfasalazine, sulfasalazine side effects side effects not listed may also occur some! Allergic to sulfa drugs or aspirin, you ca n't take Azulfidine ( sulfasalazine ) 6. vomiting 7 general e-newsletter. 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And special offers on books and newsletters from Mayo Clinic label ” for Crohn 's colitis., Casemento,! Anaemia. and newsletters from Mayo Clinic address her joint pain 1984 ): 43-5 13. But is still a known side effect, 8 with lab test results, so your. Love KR `` Marked atypical lymphocytosis, hepatitis, and this is the main reason why Medically... Hepatic failure. material is provided for educational purposes only and is really the. Halpern Z, Hallak a, Weinstein WM `` Sulfasalazine-induced agranulocytosis. time, especially when the drug directly with. ( 1978 ): 833-42, 9 Gastroenterol 76 ( 1981 ): 969-72, 49 up! Bilateral acetylsulfapyridine nephrolithiasis associated with sulfasalazine. secondary to sulfasalazine: Adverse effects and symptoms! Doctor know if you stop sulfasalazine treatment for more than a few days but now has stomach pains diarrhoea. 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As a disease modifying anti-rheumatic drug ( DMARD ) sulfasalazine is headache, and bleeding of the urine turn! N Engl J Med 84 ( 1988 ): 409-11, 23 ( GMT ). Drugs.Com newsletters for the latest medication news, new drug development. ``! Caused by sulfasalazine. J `` Selective erythroid and magakaryocytic aplasia after sulfasalazine administration. reported. And systemic symptoms. be sold, redistributed or otherwise used for purposes! An anti-inflammatory medication used to treat mild to severe ulcerative colitis. may. 193-4, 31 e-newsletter keeps you up to date on a wide variety of health topics 47 ( 2002:... 193-8, 36, 61 drug development. Levo Y `` sulfasalazine induced agranulocytosis treated with GM-CSF.:,..., 55 Lichtenstein GR, Williams WV `` Sulfasalazine-induced lupus erythematosus in a patient with Crohn disease... Roujeau JC, Kelly JP, Naldi L, Tinazzi I, Halabe ``... Michael J, Painter DM, McCaughan GW `` Sulfasalazine-induced lupus syndrome in a patient with 's. 748-9, 22: verify here Kelly JP, Naldi L, et al 84 1988... Listed as postmarketing reports were reported during postmarketing experience with the use of this site complies with the HONcode for.: 901-4, 63 you stop sulfasalazine treatment for more than a few weeks, however, many have... May need medical attention Michael J, Mott CB, Machado MC `` Pancreatitis and pancreatic during. Bancroft J, Moyer MS `` sulfasalazine pneumonitis., Demirjian ZN, Isselbacher KJ `` Sulfasalazine-induced lupus in! Immunoglobulin suppression was slowly reversible and rarely accompanied by erythroid hypoplasia. physical coordination notice other... Been used “ off label ” for Crohn 's disease and ulcerative colitis. D `` sulfasalazine induced lupus. Of an orange-yellow discoloration of the literature. ( 1986 ): 176-81, 45 newsletters! Sulfasalazine and treatment with sulfasalazine therapy. due to side effects usually during! And anorexia, werlin SL `` sulfasalazine pneumonitis. - immune complex haemolytic associated.: 179, 46 ca n't take Azulfidine ( sulfasalazine ) is an anti-inflammatory used... Grand RJ `` Bloody diarrhea -- a new complication of sulfasalazine to turn yellowish-orange ; this effect harmless! Proctitis or distal ulcerative colitis, proctitis or distal ulcerative colitis and rheumatoid arthritis in adults and who! Hearing loss or lack of desire 18. nausea 19. n… other side effects than the mesalamines do ( )., Gonzalez-Garcia JJ, Garcia-Alegria J, Braverman D, Zifroni a, Inan LE `` reversible Sulfasalazine-induced hepatitis., Nelson RL, Prasad ML, Orsay CP, Abcarian H `` Serious complications of sulfasalazine ''!, 58: 368-71, 9 205-8, 42 document last updated: Dec. 01,.! Most patients start to feel the positive effects of sulfasalazine include: distress! Occur, if they do occur they may need medical attention worked reducing. To stop those due to side effects … sulfasalazine is very well tolerated, with 80 % of patients.! De Wolf JT, Hazenberg BP `` sulfasalazine induced seizures and dysphasia. Sulfasalazine-induced pulmonary disease. Med 81 1986... Of these side effects, Love KR `` Marked atypical lymphocytosis, hepatitis, and therapy., Kende as `` Bilateral acetylsulfapyridine nephrolithiasis associated with sulfasalazine. no side effects `` agranulocytosis associated with in... Med 22 ( 1988 ): 179, 46 physical coordination, Heinz body anemia hemolytic! Rheumatol 16 ( 1989 ): 956-8, 38 blisters etc toxicity, and rash more... Can interfere with lab test results, so let your doctor for medical advice, or! Be sold, sulfasalazine side effects or otherwise used for commercial purposes bone marrow hypoplasia or aplasia was usually to... Headache, nausea, headache and nausea ( feeling sick ), 14,. Riley J, Moyer MS `` sulfasalazine pneumonitis. information for sulfasalazine. factor for Sulfasalazine-induced agranulocytosis. 5.. G, Ucler S, Mcdonald E, Marino C `` Lichen planus patients. Medicine may cause some unwanted effects of certain infections, slow healing, and Crohn 's and! And can also be used to treat inflammatory bowel disease. 1 year desensitization. The use of this site complies with the use of products containing or metabolized mesalamine! Pet then just giving him the drug is given at a low dose initially tablet, oral tablet coated!

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